The incident occurred on Tuesday evening and although the victims have not yet been identified, one of them was apparently 16 years old, Caracol Radio reported.
The youngsters were participating in a rap activity because they are members of rap bands in the urban area of that district.
On Saturday, a massacre occurred, in which five people died at a coffee farm in Betania municipality, southwest of Antioquia.
Three Venezuelans and two Colombians are among the victims.
According to the first hypothesis by the authorities, this event could be due to a confrontation among gangs for controlling micro trafficking.